In order to study the sealing performance of bolted flange connection system under high temperature condition, the thermal?structural coupling analysis of bolted flange connection system under 400.00 ℃ was carried out by Ansys?Workbench. The results show that the temperature decreases gradually from the inside of the flange wall to the outside, the maximum stress appears on the contact surface between the nut and flange, and the maximum strain appears on the gasket. Evaluated the sealing performance of gaskets at room temperature and 400.00 ℃; at the same time, aiming at the easy sealing failure of gaskets in the connection system under high temperature, established gasket strength failure of bayesian networks, based on a series of methods such as expert evaluation to calculate the prior probability, used Bayesian network reverse reasoning to calculate the posterior probability of the root node and sort them to find out the main factors leading to the invalid gasket, so as to enhance the reliability in the process of using gasket.